/* HUMANS PROJECT — page Biomarqueurs */

body.page-biomarkers {
  background: #f3f3f1;
}

.site-header__nav a[aria-current="page"]::after {
  right: 0;
}

.biomarkers-hero {
  position: relative;
  min-height: 100svh;
  overflow: hidden;
  background: #637f8d;
  color: #fff;
}

.biomarkers-hero__media,
.biomarkers-hero__scrim {
  position: absolute;
  inset: 0;
}

.biomarkers-hero__media img {
  width: 100%;
  height: 100%;
  max-width: none;
  object-fit: cover;
  object-position: 52% 50%;
  transform: scale(1.06);
  filter: saturate(.86) contrast(.94);
}

.biomarkers-hero__scrim {
  background:
    linear-gradient(90deg, rgba(22, 36, 42, .62) 0%, rgba(22, 36, 42, .35) 46%, rgba(22, 36, 42, .08) 78%),
    linear-gradient(180deg, rgba(6, 16, 20, .12), rgba(6, 16, 20, .28));
}

.biomarkers-hero__content {
  position: absolute;
  z-index: 3;
  left: clamp(28px, 8.8vw, 150px);
  top:30%;
  width: min(720px, 52vw);
  transform: translateY(-40%);
}

.biomarkers-hero__content h1 {
  margin: 0 0 clamp(20px, 2.2vw, 38px);
  font-family: var(--font-sans);
  font-size: clamp(52px, 5.15vw, 96px);
  font-weight: 500;
  line-height: .92;
  letter-spacing: -.055em;
}

.biomarkers-hero__content p {
  margin: 0;
  max-width: 46rem;
  font-size: clamp(19px, 1.38vw, 28px);
  line-height: 1.2;
  letter-spacing: -.022em;
}

.biomarkers-catalogue {
  background: #fff;
  color: #090909;
}

.biomarkers-catalogue__intro {
  padding: clamp(68px, 7vw, 120px) var(--page-pad) clamp(46px, 4vw, 72px);
  text-align: center;
}

.biomarkers-catalogue__intro h2 {
  margin: 0 auto 16px;
  font-family: var(--font-sans);
  font-size: clamp(48px, 4.55vw, 84px);
  font-weight: 500;
  line-height: .96;
  letter-spacing: -.05em;
}

.biomarkers-catalogue__intro p {
  width: min(900px, 82vw);
  margin: 0 auto;
  font-size: clamp(17px, 1.25vw, 24px);
  line-height: 1.28;
}

.biomarkers-catalogue__note {
  display: block;
  margin-top: 12px;
  color: #6c6c68;
  font-size: clamp(13px, .82vw, 16px);
}

.biomarker-groups {
  display: grid;
  grid-template-columns: repeat(3, minmax(0, 1fr));
  align-items: stretch;
  border-top: 1px solid #d5d5d0;
  border-bottom: 1px solid #d5d5d0;
  background: #f4f4f2;
}

.biomarker-group {
  position: relative;
  min-width: 0;
  min-height: clamp(520px, 48vw, 860px);
  padding: 0 clamp(28px, 3vw, 56px) clamp(52px, 5vw, 92px);
  border-right: 1px solid #d5d5d0;
  border-bottom: 1px solid #d5d5d0;
}

.biomarker-group:nth-child(3n) {
  border-right: 0;
}

.biomarker-group:nth-last-child(-n+2) {
  border-bottom: 0;
}

.biomarker-group__sticky {
  position: sticky;
  top: 0;
  z-index: 3;
  display: grid;
  grid-template-columns: auto 1fr;
  align-items: end;
  gap: 18px;
  margin: 0 calc(clamp(28px, 3vw, 56px) * -1) clamp(28px, 2.5vw, 46px);
  padding: clamp(32px, 3.4vw, 62px) clamp(28px, 3vw, 56px) clamp(22px, 2vw, 34px);
  border-bottom: 1px solid rgba(9, 9, 9, .14);
  background: rgba(244, 244, 242, .94);
  -webkit-backdrop-filter: blur(14px);
  backdrop-filter: blur(14px);
}

.biomarker-group__count {
  padding-bottom: .18em;
  color: #777772;
  font-size: clamp(13px, .84vw, 16px);
  font-variant-numeric: tabular-nums;
  line-height: 1;
}

.biomarker-group h3 {
  margin: 0;
  max-width: 13ch;
  font-size: clamp(31px, 2.25vw, 48px);
  font-weight: 500;
  line-height: .92;
  letter-spacing: -.045em;
}

.biomarker-group ul {
  margin: 0;
  padding: 0;
  list-style: none;
  font-size: clamp(15px, 1vw, 19px);
  line-height: 1.48;
}

.biomarker-group li {
  padding: .16em 0;
  text-wrap: pretty;
}

.biomarkers-approach {
  padding: clamp(78px, 7.2vw, 138px) clamp(26px, 6.7vw, 118px) clamp(90px, 8vw, 150px);
  background: #ecebea;
}

.biomarkers-approach__intro {
  display: grid;
  grid-template-columns: .92fr 1.25fr;
  gap: clamp(60px, 8vw, 150px);
  align-items: center;
  margin-bottom: clamp(80px, 7vw, 132px);
}

.biomarkers-approach__intro h2 {
  margin: 0;
  max-width: 10ch;
  font-size: clamp(50px, 5vw, 86px);
  font-weight: 500;
  line-height: .88;
  letter-spacing: -.055em;
}

.biomarkers-approach__intro-copy {
  padding-top: 12px;
}

.biomarkers-approach__intro-copy p {
  max-width: 720px;
  margin: 0 0 30px;
  font-family: var(--font-serif);
  font-size: clamp(15px, 1.5vw, 24px);
  line-height: 1.18;
  letter-spacing: -.018em;
}

.biomarker-story {
  display: grid;
  grid-template-columns: 1fr 1fr;
  gap: 14px;
  margin-bottom: 14px;
  min-height: min(520px, 42vw);
}

.biomarker-story__media,
.biomarker-story__copy {
  min-width: 0;
}

.biomarker-story__media {
  overflow: hidden;
  background: #d7d7d3;
}

.biomarker-story__media img {
  width: 100%;
  height: 100%;
  min-height: 100%;
  object-fit: cover;
}

.biomarker-story__copy {
  display: flex;
  flex-direction: column;
  padding: clamp(28px, 3.2vw, 58px);
  background: #fff;
}

.biomarker-story__copy h3 {
  margin: 0 0 30px;
  font-size: clamp(29px, 2.25vw, 46px);
  font-weight: 500;
  line-height: .98;
  letter-spacing: -.04em;
}

.biomarker-story__eyebrow {
  margin: 0 0 28px;
  color: #a4a4a0;
  font-size: clamp(13px, .85vw, 16px);
}

.biomarker-story__body {
  margin: 0;
  max-width: 92%;
  font-size: clamp(16px, 1.06vw, 20px);
  line-height: 1.32;
}

.biomarker-story__observe {
  margin-top: auto;
  padding-top: clamp(28px, 3vw, 56px);
  border-top: 1px solid #aaa;
}

.biomarker-story__observe > span {
  display: block;
  margin-bottom: 12px;
  color: #aaa;
  font-size: clamp(12px, .82vw, 15px);
}

.biomarker-story__observe ul {
  margin: 0;
  padding: 0;
  list-style: none;
  font-size: clamp(14px, .92vw, 17px);
  line-height: 1.42;
}

.biomarker-story__observe li::before {
  content: "• ";
}

.biomarkers-cta {
  position: relative;
  min-height: 86svh;
  display: grid;
  place-items: center;
  overflow: hidden;
  padding: 8vw var(--page-pad);
  background: #a80b0b url("../assets/images/biomarker-cta.webp") center / cover no-repeat;
  color: #fff;
}

.biomarkers-cta::after {
  content: "";
  position: absolute;
  inset: 0;
  background: linear-gradient(180deg, rgba(95, 0, 0, .12), rgba(95, 0, 0, .25));
  pointer-events: none;
}

.biomarkers-cta__inner {
  position: relative;
  z-index: 2;
  width: min(1120px, 92vw);
  text-align: center;
}

.biomarkers-cta__intro {
  margin: 0 auto clamp(68px, 7vw, 120px);
  max-width: 780px;
  font-size: clamp(18px, 1.35vw, 26px);
  line-height: 1.22;
}

.biomarkers-cta h2 {
  margin: 0 auto clamp(40px, 4vw, 64px);
  max-width: 18ch;
  font-size: clamp(54px, 5.1vw, 94px);
  font-weight: 500;
  line-height: .94;
  letter-spacing: -.05em;
}

.biomarkers-cta__actions {
  display: flex;
  justify-content: center;
  gap: 14px;
  flex-wrap: wrap;
}

.biomarkers-cta .button--light {
  background: #fff;
  color: #090909;
}

.biomarkers-cta .button--outline-light {
  border: 1px solid rgba(255,255,255,.9);
  background: transparent;
  color: #fff;
}

@media (max-width: 980px) {
  .biomarkers-hero__content {
    left: var(--page-pad);
    width: min(760px, 84vw);
    top: 56%;
  }

  .biomarker-groups {
    grid-template-columns: repeat(2, minmax(0, 1fr));
  }

  .biomarker-group,
  .biomarker-group:nth-child(3n) {
    border-right: 1px solid #d5d5d0;
    border-bottom: 1px solid #d5d5d0;
  }

  .biomarker-group:nth-child(2n) {
    border-right: 0;
  }

  .biomarker-group:last-child {
    border-bottom: 0;
  }

  .biomarkers-approach__intro {
    grid-template-columns: 1fr;
    gap: 40px;
  }

  .biomarkers-approach__intro h2 {
    max-width: 12ch;
  }

  .biomarker-story {
    min-height: 0;
  }
}

@media (max-width: 720px) {
  .biomarkers-hero {
    min-height: 88svh;
  }

  .biomarkers-hero__media img {
    object-position: 55% 50%;
  }

  .biomarkers-hero__content {
    top: auto;
    bottom: 10svh;
    width: calc(100% - (var(--page-pad) * 2));
    transform: none;
  }

  .biomarkers-hero__content h1 {
    font-size: clamp(46px, 15vw, 72px);
  }

  .biomarkers-hero__content p {
    font-size: 18px;
  }

  .biomarkers-catalogue__intro {
    text-align: left;
  }

  .biomarkers-catalogue__intro p {
    width: 100%;
  }

  .biomarker-groups {
    grid-template-columns: 1fr;
  }

  .biomarker-group,
  .biomarker-group:nth-child(3n),
  .biomarker-group:nth-child(2n) {
    min-height: 0;
    padding-left: var(--page-pad);
    padding-right: var(--page-pad);
    border-right: 0;
    border-bottom: 1px solid #d5d5d0;
  }

  .biomarker-group:last-child {
    border-bottom: 0;
  }

  .biomarker-group__sticky {
    grid-template-columns: 40px 1fr;
    gap: 12px;
    margin-left: calc(var(--page-pad) * -1);
    margin-right: calc(var(--page-pad) * -1);
    padding-left: var(--page-pad);
    padding-right: var(--page-pad);
  }

  .biomarker-group h3 {
    max-width: 16ch;
    font-size: clamp(30px, 9vw, 46px);
  }

  .biomarker-group ul {
    font-size: 17px;
  }

  .biomarkers-approach {
    padding-left: var(--page-pad);
    padding-right: var(--page-pad);
  }

  .biomarkers-approach__intro h2 {
    font-size: clamp(48px, 14vw, 72px);
  }

  .biomarkers-approach__intro-copy p {
    font-size: 21px;
  }

  .biomarker-story {
    grid-template-columns: 1fr;
    gap: 0;
    margin-bottom: 22px;
  }

  .biomarker-story__media {
    min-height: 54vw;
  }

  .biomarker-story__copy {
    min-height: 520px;
  }

  .biomarkers-cta {
    min-height: 78svh;
  }

  .biomarkers-cta__intro {
    margin-bottom: 52px;
  }
}

/* ============================================================
   V34 — Catalogue biomarqueurs / grille inspirée MyHealthPrac
   Les règles ci-dessous ne modifient que le catalogue.
   ============================================================ */

/* La grille garde trois colonnes, avec séparateurs pointillés fins. */
.biomarker-groups {
  align-items: stretch;
  border-top: 1px dashed rgba(20, 20, 18, .20);
  border-bottom: 1px dashed rgba(20, 20, 18, .20);
  background: #f2f2f0;
}

.biomarker-group {
  display: flex;
  flex-direction: column;
  min-height: clamp(700px, 92svh, 980px);
  padding: 0 clamp(30px, 2.25vw, 46px) clamp(34px, 3.2vw, 60px);
  border-right: 1px dashed rgba(20, 20, 18, .20);
  border-bottom: 1px dashed rgba(20, 20, 18, .20);
  background: transparent;
}

.biomarker-group:nth-child(3n) {
  border-right: 0;
}

/* On masque le compteur : il n'existe pas dans la référence visuelle. */
.biomarker-group__count {
  display: none;
}

/* Titre collant : il reste à l'écran pendant le défilement du contenu
   de sa cellule, puis cède sa place au groupe suivant. */
.biomarker-group__sticky {
  position: sticky;
  top: 0;
  z-index: 5;
  display: block;
  margin: 0 calc(clamp(30px, 2.25vw, 46px) * -1);
  padding: clamp(74px, 8.2svh, 108px) clamp(30px, 2.25vw, 46px) clamp(24px, 2.3vw, 38px);
  border-bottom: 0;
  background: rgba(242, 242, 240, .80);
  -webkit-backdrop-filter: blur(7px);
  backdrop-filter: blur(7px);
}

/* Petit voile flouté sous le titre, comme la zone de transition de la référence. */
.biomarker-group__sticky::after {
  content: "";
  position: absolute;
  left: 0;
  right: 0;
  bottom: -24px;
  height: 24px;
  pointer-events: none;
  background: linear-gradient(
    to bottom,
    rgba(242, 242, 240, .78),
    rgba(242, 242, 240, .28) 55%,
    rgba(242, 242, 240, 0)
  );
  -webkit-backdrop-filter: blur(5px);
  backdrop-filter: blur(5px);
  -webkit-mask-image: linear-gradient(to bottom, #000, transparent);
  mask-image: linear-gradient(to bottom, #000, transparent);
}

.biomarker-group h3 {
  max-width: 12ch;
  font-size: clamp(36px, 2.85vw, 56px);
  font-weight: 500;
  line-height: .88;
  letter-spacing: -.052em;
  text-wrap: balance;
}

/* Les listes sont poussées vers le bas de chaque cellule.
   Résultat : les débuts de listes s'alignent visuellement, même lorsque
   certains groupes contiennent peu de biomarqueurs. */
.biomarker-group ul {
  margin-top: auto;
  padding-top: clamp(72px, 10svh, 132px);
  font-size: clamp(15px, .98vw, 19px);
  font-weight: 450;
  line-height: 1.34;
  letter-spacing: -.018em;
}

.biomarker-group li {
  padding: .08em 0;
  text-wrap: pretty;
}

/* La dernière rangée reste propre même avec 17 groupes. */
.biomarker-group:nth-last-child(-n+2) {
  border-bottom: 0;
}

@media (max-width: 980px) {
  .biomarker-group {
    min-height: clamp(640px, 88svh, 900px);
  }

  .biomarker-group:nth-child(3n) {
    border-right: 1px dashed rgba(20, 20, 18, .20);
  }

  .biomarker-group:nth-child(2n) {
    border-right: 0;
  }

  .biomarker-group__sticky {
    padding-top: clamp(58px, 7svh, 88px);
  }
}

@media (max-width: 720px) {
  .biomarker-group,
  .biomarker-group:nth-child(3n),
  .biomarker-group:nth-child(2n) {
    min-height: 76svh;
    padding-left: var(--page-pad);
    padding-right: var(--page-pad);
    border-right: 0;
    border-bottom: 1px dashed rgba(20, 20, 18, .20);
  }

  .biomarker-group__sticky {
    margin-left: calc(var(--page-pad) * -1);
    margin-right: calc(var(--page-pad) * -1);
    padding-left: var(--page-pad);
    padding-right: var(--page-pad);
    padding-top: 52px;
  }

  .biomarker-group h3 {
    max-width: 11ch;
    font-size: clamp(38px, 11vw, 58px);
  }

  .biomarker-group ul {
    padding-top: 72px;
    font-size: 16px;
  }
}